Domperidone (Motilium Tablet) – Uses, Dosage, Side Effects & Safety Guide in Pakistan
What is Domperidone (Motilium)? Domperidone is a prokinetic and anti-emetic medicine used to treat nausea , vomiting , bloating , gastric reflux , and delayed stomach emptying (gastroparesis) . In Pakistan, it is commonly available under brand names like:- Motilium Domel Domper Peridon and other local brands It works by increasing stomach movement and preventing nausea signals from reaching the brain. How Domperidone Works (Mechanism of Action) Domperidone blocks dopamine (D2) receptors present in the gut and vomiting center of the brain. This leads to: Faster stomach emptying Improved intestinal movement Reduced nausea and vomiting Relief from gas, bloating, and reflux symptoms Unlike many anti-vomiting medicines, domperidone does not cause major drowsiness . Feature Details Absorption Rapid oral absorption Peak level 30–60 minutes Bioavailability ~15% Protein binding ~90% Metabolism Liver Half-li...